Indian Journal of Pathology and Oncology

Official Publication of Innovative Education and Scientific Research Foundation


Volume 12, Issue 2, Year 2025
Editorial
A mini review of cryptic lesions of the breast
Author details: Banushree CS*
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Review Article
NF-kB–p53 axis antagonism: A therapeutic opportunity in cancer treatment
Author details: Ranjeet Kumar, Deepika Biswas
P53 and NF-xB pathways play a crucial role in inflammatory regulation, cell proliferation, tumour suppression, cell apoptosis, synaptic plasticity, memory of cells, etc. These pathways often get crippled by mutation thereby leading to tumour formation and eventually cancer. P53 is a transcription fa....
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Original Article
Efficacy of cytology in small round cell tumours
Author details: Deepika Rani, Nidhi Verma
Background: Malignant small round cell tumours are characterized by small, round, relatively undifferentiated cells sharing similar histology when visualized under light microscope. These typically encompass Ewing’s sarcoma, peripheral neuroectodermal tumour (PNET), rhabdomyosarcoma, synovial sarcom....
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Correlation of clinico hematological profile in confirmed cases of dengue
Author details: Fatima Iqbal Maniyar, Ramesh Chavan, Umair ul Basheer
Background: Dengue Fever is a self - limiting illness which is spread by the bite of Aedes aegypti mosquito. WHO estimates about 50-100 million dengue cases every year. Nearly 300,000 cases of dengue hemorrhagic fever are reported with 24,000 deaths every year. In India dengue fever has become more....
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Assessing the rate of malignancy in Bethesda category III thyroid nodules and its correlation with histopathology
Author details: Lakshmi Agarwal, Hitisha Kumawat, Kalpit Jain, Manmohan Agrawal
Background: Fine-needle aspiration cytology (FNAC) is a key diagnostic tool for evaluating thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) classifies thyroid nodules into six categories, with Category III (Atypia of Undetermined Significance - AUS) presenting diagno....
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Unveiling liver pathology in autopsy cases
Author details: Bharati M Bhavikatti, Kanchana U T, Darshitha B, Harshitha G V, Ankita Ashok Muktawar
Background: Liver constitute the site of many diseases and involved in various kinds of inflammatory, neoplastic and other lesions. Liver is the most common site for metabolic functions which is prone to get various type of injury due to exposure of chemicals, toxins and drugs. Autopsy examination s....
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Intraoperative frozen section study of ovarian tumours
Author details: Priya Garg, Sheeladevi Chandakavadi Shivalingaiah, Deepika Gurumurthy, Shashirekha Basavaraju
Background: Ovarian neoplasms are a heterogenous group of tumours with diverse treatment for different tumours. Intraoperative frozen section (IFS) is an important diagnostic tool for differentiating benign from malignant ovarian tumours. The precision of diagnosis of ovarian neoplasms by frozen sec....
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Clinico pathological spectrum of bone lesions in a five year study in a tertiary care centre
Author details: Meera Bhanu, Sateesh S Chavan, Kanchana Jayaram, Amaya Bhaskaran, Sunita Vernekar
Background: Bone lesions exhibit a wide range of characteristics and their trends vary according to age, clinical features, and the frequency of the different histological types. The objective of our study is to investigate the clinical and pathological spectrum of bone lesions, focusing on their in....
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Correlation of morphological changes with demographical and clinicopathological parameters in cholecytectomy specimen
Author details: Garima Dwivedi, Abha Singh
Background: Gall bladder carcinoma is the most common gastrointestinal cancer in Indian having poor prognosis due to advanced stage at presentation. There is marked geographical variation in the prevalence of GB carcinoma worldwide .Among the developed countries it is more prevalent in South America....
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Immunohistochemical expression of HER1, HER2, HER3 and HER4 in head and neck squamous cell carcinoma
Author details: Devika Kinkhede, Meena Pangarkar, Radhika Praveen Pagey, Prajakta Sathawane, Shweta Ashok Deulkar, Shraddha Rajan Mahindra, Yogita Devi
Background: Lip, oral cavity cancers are ranked as the sixteenth most common cancer worldwide according to the latest GLOBOCAN estimates (2022). The determination of expression of ERBB receptors in head and neck squamous cell carcinoma (HNSCC) can help profile the patients, potentially devise newer....
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Cytomorphological variations in Hashimoto’s thyroiditis: A study of 164 cases
Author details: Arunima Mallick, Sateesh Chavan S, Sunita S Vernekar
Background: Hashimoto’s thyroiditis is the second most common cause of hypothyroidism following goiter and FNAC has been found to be one of the essential procedures done to diagnose it. Our aim is to analyse the cytomorphological diversity of this disease along with the biochemical profile correlati....
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Case Report
A rare presentation of Marjolin ulcer in burn scar in popliteal fossa
Author details: Ritwik Kaushik, Ankush Nayyar
The squamous cell carcinoma in a long-standing chronic scar is a well-known clinical entity. Such lesions are also called Marjolin’s ulcer (MU). Marjolin’s ulcer can form following any trauma, unattended wounds, but most commonly burn scars which were left ungrafted. In this case report, we present....
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Myxopapillary ependymoma with anaplastic features: A rare case report
Author details: Rajavigneshwari Nagarajan, Salapathi Shanmugam, Rajeshwari Buttannavar, Siddhartha Ghosh
Myxopapillary ependymoma (MPE) is a typically encountered neoplasm in the filum terminale/lumbosacral region of the spinal cord, categorised as a grade 2 tumour in the latest 2021 WHO classification of tumours of the CNS. Despite its usual indolent behaviour, cases in extradural locations may exhibi....
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Bilateral branchial cleft cysts with primary papillary thyroid carcinoma concealed within left branchial cleft cyst: An unusual presentation
Author details: Neelam Sood, Ruhi
Branchial cleft cysts are lateral cystic neck lesions, usually presenting in 2nd to 4th decade of life, due to incomplete obliteration of the branchial apparatus. Bilateral presentation is an infrequent occurrence. Sometimes they may harbour normal thyroid tissue but rarely present with primary papi....
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Uterine angiosarcoma: A diagnostic challenge in an uncommon uterine tumor (A case report)
Author details: Abderrahmane Mellouki, Asmaa Houzi, Adnane Boulmani, Mehdi Karkouri,, Souha Sahraoui
Uterine angiosarcoma is exceedingly rare, with few cases reported in literature. The prognosis is very poor, and no standardized treatment protocol has been established to date. We report here a 54-year-old postmenopausal woman with no significant medical history, including no prior uterine fibroids....
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Mucinous carcinoma of male breast: A rare case report
Author details: Manmeet Kaur, Arpita Kumar
Less than 1% of recorded malignancies in men are related to breast cancer. In comparison to women who share similar risk factors, male breast cancer has a poorer prognosis which can be attributed to lack of awareness and late presentation. A 63 year old male presented to the surgery OPD with a rapid....
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Malignant melanotic nerve sheath tumour: A rare and curious entity
Author details: Rajalaxmi Gobburkar, Madhusmita Jena, Kumaran C, Kavyashri H. B
Malignant melanotic nerve sheath tumour (MMNSTs), earlier known as melanotic schwannoma, is an extremely rare variant of peripheral nerve sheath tumour arising from Schwann cells which is characterised by its ability to produce abundant melanin pigment. The melanotic schwannoma is a very rare neopla....
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The mystery of free-floating peritoneal loose body: An incidental intraoperative finding in a case of hernioplasty
Author details: Azhagunila Adinarayanane, Umasankary Calaisselvane, Banushree CS, Mima Maychet B Sangma
Background: Peritoneal loose body (PLBs) is an unusual presentation occurring as a free-floating mass in the peritoneal cavity. They remain asymptomatic for longer periods but may produce vague abdominal pain on occasion. They are generally an incidental finding during imaging studies, surgery or au....
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“CAVERNS” of vessels in a male breast: a rare site for hemangioma
Author details: Varaprasad B M, Nidhi Radhakrishnan, Varsha S
Incidence of male breast lesions has increased by 1.6% in the last two decades. Nevertheless, hemangioma of breast is seldom encountered in clinical practice (0.8%) and its incidence in male breast is unknown due to extreme rarity. A 72 year old male, with 40 years history of slowly progressing, pai....
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A rare presentation of extraosseous ewing sarcoma in a 14-year-old boy with pleural involvement
Author details: Rajesh Raju, Sulbha M. Arya, Ipshita Raju, Banuru Prasad, Sanjeev Saini, Sharath Burugina Nagaraja
Extraosseous Ewing Sarcoma (EES) is a rare subtype of Ewing Sarcoma which originates usually in soft tissues when compared to bones. We present the case of a 14-year-old boy presenting with an atypical painless swelling on the left side of the chest and pleural effusion. On evaluation that included....
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Comprehensive management of multiple endocrine neoplasia Type 2A (MEN2A): A multidisciplinary approach
Author details: Neelima Gupta, Nimisha Srivastava, Jyoti Verma, Pranjal Srivastava
Background: Multiple Endocrine Neoplasia Type 2A (MEN2A) is an autosomal dominant disorder characterized by medullary thyroid carcinoma (MTC), pheochromocytomas, and hyperparathyroidism. Early identification through genetic testing for RET proto-oncogene mutations and appropriate surgical interventi....
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Aggressive renal myxoid liposarcoma with co-existing bilateral benign angiomyolipoma: A rare case report
Author details: Dhivya Nanjundamoorthi, Shobhanaa Pechimuthubabu Seethalakshmi, Annapurneswari Subramanian
This report describes a 71-year-old male with Primary renal myxoid liposarcoma (MLPS), who presented with left loin pain and mass per abdomen. Computed Tomography (CT) revealed a complex mass in the left kidney with a right renal angiomyolipoma. There were two distinct lesions on gross examination.....
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A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia
Author details: Pallavi S Ladda, Manasi Mundada, Faiq Ahmed, Senthil J Rajappa
Non-seminomatous germ cell tumors have been not more frequently linked to Acute Myeloid Leukemia (AML) (M7), a rare form of primary AML. Review of literature regarding the case has shown that there were 26 case reports of concomitant mediastinal non seminomatous germ cell tumors in the last seven de....
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