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- DOI 10.18231/j.ijpo.51587.1760700391
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CrossMark
Low-grade sinonasal non-intestinal type adenocarcinoma (Non-ITAC): A rare case report
- Author Details:
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Vishalaxi H Patil *
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Sameer P Ahamed
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Soumya BM
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Rashmi P
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Vardendra Kulkarni
Vishalaxi H Patil *
Sameer P Ahamed
Soumya BM
Rashmi P
Vardendra Kulkarni
Low-grade non-intestinal type sinonasal adenocarcinoma (SNAC) is a rare heterogenous group of tumours, distinct from intestinal and salivary type neoplasm. Low-grade type have more favourable prognosis compared to aggressive high grade. We report a case of low-grade non -intestinal type SNAC in a 50 year old female, presented with nasal discharge and blockage since one year. CT findings prompted a provisional diagnosis of pansinusitis with right choanal polyp. Microscopy revealed a neoplastic lesion arranged in tubulo-papillary and glandular architecture with glands lined by single layer of bland columnar cells with a foci of invasion and no mitotic activity. Immunohistochemistry revealed CK7 and SOX10 positivity with CK20 negativity, favouring a diagnosis of low-grade non-intestinal SNAC. This case underscores the importance of histomorphology and IHC in differentiating it from other benign lesions and intestinal type SNACs.
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