Low-grade sinonasal non-intestinal type adenocarcinoma (Non-ITAC): A rare case report

• Author Details:   
• Vishalaxi H Patil ^*
• Sameer P Ahamed
• Soumya BM
• Rashmi P
• Vardendra Kulkarni

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Low-grade non-intestinal type sinonasal adenocarcinoma (SNAC) is a rare heterogenous group of tumours, distinct from intestinal and salivary type neoplasm. Low-grade type have more favourable prognosis compared to aggressive high grade. We report a case of low-grade non -intestinal type SNAC in a 50 year old female, presented with nasal discharge and blockage since one year. CT findings prompted a provisional diagnosis of pansinusitis with right choanal polyp. Microscopy revealed a neoplastic lesion arranged in tubulo-papillary and glandular architecture with glands lined by single layer of bland columnar cells with a foci of invasion and no mitotic activity. Immunohistochemistry revealed CK7 and SOX10 positivity with CK20 negativity, favouring a diagnosis of low-grade non-intestinal SNAC. This case underscores the importance of histomorphology and IHC in differentiating it from other benign lesions and intestinal type SNACs.