Role of glial fibrillary acidic protein (GFAP) marker in central nervous system lesions

---

Original Article

Author Details : Geeta W. Mukhiya, Gulshan K. Mukhiya, KK Bansal

Volume : 4, Issue : 3, Year : 2017

Article Page : 465-467

Suggest article by email

Get Permission

---

Abstract

Introduction: The subject of tumours of the nervous system is often looked upon with apprehension by medical practitioners as central nervous system tumours constitute 1-2% of all the neoplasms. Gliomas constitute 38.7% of CNS tumours in which high grade gliomas are 59.5% of patients with systemic malignancies develop brain metastasis during their disease.
Glial fibrillary protein is the most frequently used marker in diagnostic neuro-oncology. Positive reaction to GFAP has been demonstrated in astrocytomas, ependymoma and astrocytic cells of mixed gliomas, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, astroblastoma and gliosarcoma.
Aim of the study: In the present study the main aim is to differentiate glial tumours from other lesions by morphology and confirmation by using Glial Fibrillary Acidic Protein (GFAP) immunostaining.
Results: In the present study glial tumors formed the largest group of cases (44 cases; 41.9%) diagnosed on cytology. They were further divided into low grade and high grade glioma / astrocytoma (33 cases, 31.4%), oligodendroglioma (1 case, 0.95%) and ependymoma (7 cases, 6.6%) based on cytological features. Subsequently, as shown in table IX, the cytohistopathological correlation for glioma / astrocytoma was 91.6%. There were 10 cases which turned out to be oligodendroglioma (4 cases, 11.1%), ependymoma (4 cases, 11.1%) and ganglioglioma (2 cases, 6.0%).

Keywords: GFAP, Glial Fibrillary Protein, Astrocytomas, Ependymoma

How to cite : Mukhiya G W, Mukhiya G K, Bansal K, Role of glial fibrillary acidic protein (GFAP) marker in central nervous system lesions. Indian J Pathol Oncol 2017;4(3):465-467

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.