FIP1L1– PDGFRA positive chronic eosinophilic leukemia: A case report

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Case Report

Author Details : Richa Bhartiya*, Sujata Agrawal, Poornakala S , Nina G Desai

Volume : 10, Issue : 4, Year : 2023

Article Page : 398-400

https://doi.org/10.18231/j.ijpo.2023.089

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Abstract

Chronic eosinophilic leukemia (CEL) is a rare type of leukemia which is characterized by persistently increased number of eosinophils in peripheral blood and bone-marrow alongwith evidence of clonal proliferation of eosinophils with tissue infiltration by eosinophils leading to organ damage and causing systemic manifestations. An accurate diagnosis of CEL is essential as these patients show excellent response to imatinib mesylate. Use of technique like FISH (fluorescent in-situ hybridization) & RTPCR (Reverse Transcriptase) helps in proving the clonality of eosinophils. We report a case of CEL with FIP1L1 (Fip1-Like-1) PDGFRA (Platelet Derived Growth Factor Receptor – Alpha Gene) mutation in 29-year old male presenting with persistent eosinophilia. Rarity of this entity definitely needs a space in literature.
 

Keywords: Chronic eosinophilic leukemia, FIP1L1 -PDGFRA, Hyper Eosinophilic Syndrome, Imatinib mesylate.

How to cite : Bhartiya R, Agrawal S, Poornakala S, Desai N G, FIP1L1– PDGFRA positive chronic eosinophilic leukemia: A case report. Indian J Pathol Oncol 2023;10(4):398-400

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