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- DOI 10.18231/j.ijpo.2019.052
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CrossMark
- Citation
A study of hematological indices and bone marrow morphology in patients presenting with anemia
- Author Details:
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Shivaji Dadarao Birare
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Neeraj Jain
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Rahul S Abhange *
Introduction: The initial workup of anemia includes assessment of hematological indices and examination of the peripheral blood smears. Laboratory evaluation without marrow examination is usually not confirmatory. The objective of this study is to find the underlying etiopathology of anemia and correlate hematological indices, bone marrow study with clinical examination findings in differentiating causes of anemia.
Materials and Methods: The present observational study was carried out on 138 patients with anemia, in which bone marrow study (BM aspiration and biopsy) was done for evaluation.
Pediatrics population below 15 years and pregnant female and patients who did not give consent for bone marrow aspiration or biopsy were excluded from the study.
Results: Dimorphic anemia was the most common non-malignant hematological cause followed by megaloblastic anemia. In hematological malignancies acute myeloid leukemia (4.34%) was most common.
Discussion: A comprehensive clinical and hematological study of patients with anemia of various hematological disorders will usually help in identification of underlying cause. However, in view of wide array of etiologies, finding of underlying etiopathology continues to be a challenge for pathologist and hematologists.
Keywords: Anemia, Hematological indices, Bone marrow study.
References
- Tahlan A, Bansal C, Palta A, Chauhan S. Spectrum and analysis of bone marrow findings in anemic cases. Indian J Med Sci 2008;62:62:336-9.
- Patel KV, Harris TB, Faulhaber M, Angleman SB, Connelly S, Bauer DC, Kuller LH, Newman AB, Guralnik JM. Racial variation in the relationship of anemia with mortality and mobility disability among older adults. Blood 2007;109:4663-
- Bain BJ. (2006) Morphology of blood cells. In: Blood Cells.4th ed. Blackwell Publishing:70.
- Nasrin A. Qureshi, Mohammed Abid Z. Chauhan, A.P. Goswami, S.K Suri. Study of anemia and its correlation with Hematological parameters in patient of various age group. IOSR-JDMS 2015;14(9):29-35.
- Egesie OJ, Joseph DE, Egesie UG, Ewuga OJ. Epidemiology of anemia necessitating bone marrow aspiration cytology in Jos. Niger Med J 2009;50:61-3.
- Kibria SG, Islam MDU, Chowdhury ASMJ. Prevalence of hematological disorder: a bone marrow study of 177 cases in a private hospital at Faridpur. Faridpur Med Coll J 2010;5:11-3.
- Pudasaini S, Prasad KBR, Rauniyar SK, Shrestha R, Gautam K, Pathak R, Koirala S. et al. Interpretation of bone marrow aspiration in hematological disorder. J Pathol Nepal 2012;2:309-12.
- Barbara J Babin, Imelda, Bates, S. Mitchell Lewis. Decie and Lewis practical haematology. Reference ranges and normal value 2011;11(2):10-25.
- Javalgi AP, Dombale VD. Clinico β Hematological Analysis of Pancytopenia: A Bone Marrow Study. Natl J Lab Med 2013;2(4):12-17.
- Shastry SM, Kolte SS.Spectrum of hematological disorders observed in one-hundred and ten consecutive bone marrow aspirations and biopsies. Med J DY Patil Univ 2012;5:118-21.
- Anjum MU, Shah SH, Khaliq MA. Spectrum of hematological disorders on bone marrow aspirate examination. Gomal J Med Sci 2014;12:193-6.
- Dasgupta S, Mandal PK, Chakrabarti S. Etiology of Pancytopenia: An observation from a referral medical institution of Eastern Region of India. J Lab Physicians 2015;7:90-5. Shivaji Dadarao Birare et al. A study of hematological indices and bone marrow morphology in patients presenting⦠Indian Journal of Pathology and Oncology, April-June, 2019;6(2):266-274 274
- Pudasaini S, Prasad KBR, Rauniyar SK, Shrestha R, Gsautam K, Pathak R, Koirala S, et al. Interpretation of bone marrow aspiration in hematological disorder. J Pathol Nepal 2012;2:309-12.
- Gayathri BN, Satyanarayan Rao K. Pancytopenia- A Clinico Hematological Study. J Lab Physicians 2011;3(1):15-20.
- Patel J, Popat VC. Spectrum of hematological disorders observed in consecutive 150 cases on bone marrow examination. Int J Res Med 2014;3(2);139-41.
- Tahlan A, Bansal C, Palta A, Chauhan S. Spectrum and analysis of bone marrow findings in anemic cases. Ind J Med Sci 2008;62:336-9.
- Tariq M, N, Basri R, Amin S. Aetiology of pancytopenia. Prof Med J 2010;17(2):252-6.
- Thiyagarajan P, Narayanarao Suresh T, Anjanappa R, Harendra Kumar ML. Bone-marrow spectrum in a tertiary care hospital: Clinical indications, peripheral smear correlation and diagnostic value. Med J Dr DY Patil Univ 2015;8(4):490-4.
- R Athar, Y Khonglah, V Raphael, A Pal, K G Lynrah. Clinico- Hematologic and Biochemical Profile of Dimorphic Anemia with Bone Marrow Study. The Internet J Lab Med 2014;6:1.
- Pujara KM, Bhalara RV, Dhrva GA. A study of bone marrow iron storage in hematological disorders. Int J Health Allied Sci 2014;4(3):221-4.
- Jha A, Sayami G, Adhikari RC, Panta AD, Jha R. Bone Marrow Examination in Cases of Pancytopenia. JNMA 2008;7(169):12-17.
- Kumar R, Kalra SP, Kumar H, Anand AC, Madan H. Pancytopenia - A six year Study. JAPI 2001;49:1078-81.
- Haq S, Iqbal N, Fayyaz F, Tasneem T. Serum B12 and folate levels in patients with megaloblastic change in the bone marrow. Biomedica 2012;28.
- Khattak MB, Ismail M, Marwat ZI, Khan F. Frequency and characterisation of pancytopenia in megaloblastic anaemia. J Ayub Med Coll Abbottabad 2012;24:3-4.
- Tilak V, Jain R. Pancytopenia-a clinicopathologic analysis of 77 cases. Indian J Pathol Microbiol 1999;42:399-404.
- Khodke K, Marwah S, Buxi G, et al. Bone marrow examination in cases of pancytopenia. J Indian Acad Clin Med 2001;2:55-9.
- Mahendra Singh, Anuradha Gautam. To Evaluate Anaemia by Erythrocyte Indices, Red Cell Distribution width and Haemoglobin Electrophoresis with Special Reference to Thalassemia in Paediatric Age Group. JMDS 2015;4(11):1755-
- Daniel NM, Byrd S. Aplastic anemia: an analysis of 50 cases. Ann Intern Med 1958;49: 326-36.
- Haldar B, Pal Partha P, Tarun Kumar S, Sharma S,Goswami B, Aikat A. Aplastic Anemia: A Common Hematological Abnormality Among Peripheral Pancytopenia. N Am J Med Sci 2012;4(9):384β8.
- Al-Khalisi KA, Al-Zubaidy AS, Rhaima M. Pancytopenia Adult Patients at Baghdad Teaching Hospital. Iraqi Postgrad Med J 2011;10(4).
- Hamid GA, Nabhi A. Clinicoepidemiological features of adult leukemias in Aden Yemen. Ind J Applied Res 2015;5(7):334-6.
- Metikurke SH, Rashmi K, Bhavika R. Correlation of Bone Marrow Aspirate, Biopsies and Touch Imprint Findings in Pancytopenia. J Hematol 2013;2(1):8-13.
How to Cite This Article
Vancouver
Birare SD, Jain N, Abhange RS. A study of hematological indices and bone marrow morphology in patients presenting with anemia [Internet]. Indian J Pathol Oncol. 2019 [cited 2025 Oct 16];6(2):266-274. Available from: https://doi.org/10.18231/j.ijpo.2019.052
APA
Birare, S. D., Jain, N., Abhange, R. S. (2019). A study of hematological indices and bone marrow morphology in patients presenting with anemia. Indian J Pathol Oncol, 6(2), 266-274. https://doi.org/10.18231/j.ijpo.2019.052
MLA
Birare, Shivaji Dadarao, Jain, Neeraj, Abhange, Rahul S. "A study of hematological indices and bone marrow morphology in patients presenting with anemia." Indian J Pathol Oncol, vol. 6, no. 2, 2019, pp. 266-274. https://doi.org/10.18231/j.ijpo.2019.052
Chicago
Birare, S. D., Jain, N., Abhange, R. S.. "A study of hematological indices and bone marrow morphology in patients presenting with anemia." Indian J Pathol Oncol 6, no. 2 (2019): 266-274. https://doi.org/10.18231/j.ijpo.2019.052