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Factors affecting platelet yield in single donor plateletpheresis: A single institution experience
- Author Details:
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Ch. Geetha
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M. Pavani
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Padmaja Korti
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E. Jayashankar
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AK Deshpande
Transfusion of single donor platelets (SDP) is emerging as effective therapy in patients with platelet(PLT) insufficiencies with the advantage of preventing alloimmunisation and transfusion related infections by limiting recipient’s exposure to platelets from multiple donors.
The aim of the present study is to analyze the effect of various donor and procedure related parameters on the yield of single donor platelets facilitating effective screening of blood donors in less time.
Materials and Methods: It is a reterospective study of one hundred and nine plateletpheresis procedures performed at our (tertiary-care) hospital over a period of 16 months.The procedure was carried on Fresinius. Kabi COM.TEC apheresis machine (contious flow cell seperator) using closed system kits, single needle procedure with program selected 5d-SN. Statistical analysis was done with SPSS software to find the extent of relationship between different variables using “r” value and “p” value.
Results: Age, weight, plateletcount,haemoglobin(Hb), total leucocyte count(TLC) and blood volume processed of donors, processing time of machine had significant positive correlation with platelet yield. ABO group did not show any correlation with platelet yield.Rh negative donors had longer processing time than Rh positive donors.
Conclusion: Platelet yield correlated positively with pre-donation platelet count, weight, haemoglobin, processing time and blood volume processed. Optimization of platelet yield by identifying donor factors may help in selecting donors to obtain higher platelet yields in shorter time and consequently better clinical outcome.
Keywords: Plateletpheresis; Haemoglobin; Total leucocyte count; Weight; Platelet Count; Platelet yield
References
- Wallace EL, Churchill WH, Surgenor DM, Cho GS, McGurk S. Collection and transfusion of blood and blood components in the United States, 1994. Transfusion 1998;38:625-36.
- Goodnough LT, Ali S, Despotis G, Dynis M, DiPersio JF. Economic impact of donor platelet count and platelet yield in apheresis products: relevance for emerging issues in platelet transfusion therapy. Vox Sang 1999;76:43-9.
- Chambers LA, Kruskall MS, Pacini DG, Donovan LM. Febrile reactions after platelet transfusion: the effect of single versus multiple donors. Transfusion 1990;30:219-
- 4.Gmür J, von Felten A, Osterwalder B, Honegger H, Hörmann A, Sauter C et al. Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia. Blood 1983;62:473-9.
- Patel J, Nishal A, Pandya A, Patel P, Wadhwani S. Factors influencing yield of platelet aphaeresis using continuous flow cell separator. Int J Med Sci Public Health 2013;2:309-12.
- Guerrero-Rivera S, Gutiérrez-Espíndola G, Talavera JO, Meillón- García LA, Pedraza-Echevarría M, Pizzuto- Chávez J. Haemoglobin and platelet count effect on platelet yields in plateletpheresis. Arch Med Res 2003;34:120-3.
- Drugs and Cosmetic Act 1940. 16th ed. Lucknow; Eastern Book Company; 2003. p.279-303.
- Das SS, Chaudhary RK, Shukla JS. Factors influencing yield of plateletpheresis using intermittent flow cell separator. Clin Lab Haematol 2005;27:316-9.
- Chaudhary R, Das SS, Khetan D, Sinha P. Effect of donor variables on yield in single donor plateletpheresis by continuous flow cell separator. Transfus Apher Sci 2006;34:157-61.
- Enein AA, Hussein EA, El Shafie S, Hallouda M. Factors affecting platelet yield and their impact on the platelet increment of patients receiving single donor PLT transfusion. J ClinApher 2007;22:5-9.
- Arun R, Yashovardhan A, Deepthi K, Suresh B, Sreedhar Babu KV, Jothibai DS. Donor demographic and laboratory predictors of single donor platelet yield. J Clin Sci Res 2013;2:211-5.
- Mangwana S. Influence of donor demographics on the platelet yield during plateletpheresis - experience of 1100 procedures at a tertiary-care hospital. Journal of Pathology of Nepal 2014;4:525 -29.
- Prince TH, editor. Standards for blood banks and transfusion services. 25th edition. Bethesda: MD: AABB,
- p.36.
- Council of Europe. Guide to the preparation, useand quality assurance of blood components. 12 th edition. Strasbourg: Council of Europe Publishing.
How to Cite This Article
Vancouver
Geetha C, Pavani M, Korti P, Jayashankar E, Deshpande A. Factors affecting platelet yield in single donor plateletpheresis: A single institution experience [Internet]. Indian J Pathol Oncol. 2017 [cited 2025 Oct 06];4(1):23-26. Available from: https://doi.org/
APA
Geetha, C., Pavani, M., Korti, P., Jayashankar, E., Deshpande, A. (2017). Factors affecting platelet yield in single donor plateletpheresis: A single institution experience. Indian J Pathol Oncol, 4(1), 23-26. https://doi.org/
MLA
Geetha, Ch., Pavani, M., Korti, Padmaja, Jayashankar, E., Deshpande, AK. "Factors affecting platelet yield in single donor plateletpheresis: A single institution experience." Indian J Pathol Oncol, vol. 4, no. 1, 2017, pp. 23-26. https://doi.org/
Chicago
Geetha, C., Pavani, M., Korti, P., Jayashankar, E., Deshpande, A.. "Factors affecting platelet yield in single donor plateletpheresis: A single institution experience." Indian J Pathol Oncol 4, no. 1 (2017): 23-26. https://doi.org/