Histopathological patterns of endometrial lesions in patients with abnormal uterine Bleeding in rural area of Western Maharashtra

• Author Details:   
• Swati Bapurao Mune
• Abdul Gafoor Karche

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Background: Abnormal uterine bleeding (AUB) is considered one of the most common and challenging problems presenting to the gynecologist. Histopathological examination of endometrial biopsy is gold standard diagnostic tool in evaluation of AUB. Our study is aimed at determining the spectrum of endometrial pathologies in different age group patients presenting with AUB at our hospital which caters largely to women living in rural area.
Methods: This was a retrospective study done on patients presenting with AUB over the period Jan 2013- Dec.2015, in Department of Pathology, Ashwini rural medical college and research centre, Kumbhari, Tq. South Solapur, in Western Maharashtra(India). The histopathological findings of AUB were categorized into functional and organic causes. A detailed histological study was carried out and the findings were noted. A statistical analysis between age of presentation and a specific endometrial cause was done using chi-square test.
Results: The most common age group presenting with AUB was 41- 50 yrs (42%). Mean age for women presented with AUB was 44.2 years. The commonest pattern in these patients was normal cyclical endometrium (33.9%): Proliferative and secretory phase. The commonest pathology was endometrial hyperplasia (22.2%). Other causes identified were disordered proliferative endometrium(13.7%), atrophic endometrium(13.2%), benign endometrial polyp(8%), deficient secretory phase(3.3%), chronic endometritis(2.4%), and endometrial carcinoma(2.3%). It has been observed that, there was highly significant association between age group and histopathological diagnosis (p<0.01).
Conclusions: Histopathological examination of endometrium is gold standard diagnostic tool in evaluation of AUB and there is an age specific association of endometrial lesions.

Keywords: Abnormal uterine bleeding (AUB); dysfunctional uterine bleeding (DUB); Endometrial hyperplasia