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Role of fine needle aspiration cytology in diagnosis of various giant cell lesions of bone and its Histopathological correlation
- Author Details:
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Mohammad Jaseem Hassan
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Sabina Khan
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Nihal Ahmad
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Kafil Akhter
Introduction: Correct diagnosis is a matter of supreme importance because the treatment varies in different types of musculoskeletal tumors and in conditions simulating these tumors. Because of limited presence of literature for cytological diagnosis of giant cell lesions of the bone, we conducted this study to assess the reliability of Fine needle aspiration cytology in diagnosis of giant cell lesion of the bone and correlating our findings with final histopathological diagnosis.
Method: The superficial and deeply located bone lesions were localized with the help of radiographs. For aspiration of superficial lesions 22-23 gauge needles was used along with 10 ml disposable syringe, while for deeply located lesion 20 gauge needles was used. The cytological smears were then stained by May Grunwald Giemsa and Hematoxylin and eosin stain.
Result: During the period of one and half years, cytological diagnosis of giant cell lesions was made in 27 cases on FNAC. The mean age of the patient was 21.7 years with male to female ratio of 1.25:1. Maximum number of cases (18/27 cases) was encountered in 11-30 year age group. Tibia was the most common bone involved (12 cases) followed by femur and humerus (5 cases each). On final histopathological evaluation various giant cell lesions consist of 16 cases of Giant cell tumor, 5 cases of aneurysmal bone cyst and 3 cases each of Fibrous dysplasia and Chondromyxoid fibroma.
Conclusion: Despite limited literature we wish to recommend fine needle aspiration cytology as initial tool for differentiation of various giant cell lesions especially in conjunction with clinical and radiological findings.
Keywords: ABC, Bone tumors, FNAC, Giant cell lesions, GCT
References
- Mankin HJ, Lange TA, Spanier SS: The hazards of biopsy in patients with malignant primary bone and soft tissue tumors. J Bone Joint Surg Am 1982;64:1121-1127.
- Simon MA: Current concept review -biopsy of musculoskeletal tumors. J Bone Joint Surg Am 1982;64:1253-1257.
- EI Khoury GY, Terepka RH, Mickelson MR, Rainville KL, Zaleski MS: Fine needle aspiration biopsy of bone. J Bone Joint Surg 1983;65:522–525.
- Pai MR, Coimbatore RV, Naik R, Lugade M: Role of Fine needle aspiration cytology in the diagnosis of bone tumors. J Cytol 2002;19:33–39.
- Rosai J. 2005. Bone and joints. In Rosai and Ackerman’s Surgical Pathology, 9th ed(vol 2). Mosby, Missouri, 2005: p2171.
- Agarwal PK, Wahal KM: Cytopathologic study of primary tumors of bone and joints. Acta Cytol 1983;27:23–27.
- Sherwani R, Akhtar K, Abrari A, Sherwani K, Goel S, Zaheer S: Fine needle aspiration cytology in the management of tumors and tumor like Lesions of Bone. JK Science 2006;8:151-156.
- Agarwal S, Agarwal T, Agarwal R, Agarwal PK, Jain UK: Fine needle aspiration of bone tumors. Cancer Detect Prev 2000;24:602-609.
- Pai MR, Coimbatore RV, Naik R, Lugade M: Role of Fine needle aspiration cytology in the diagnosis of bone tumors. J Cytol 2002;19:33–39.
- Khan AR, Mir BA: FNAC- Giant cell tumor of bone a study of 13 cases (part III). J K Practitioner 2003;10:236-
- Nnodu OE, Giwa SO, Samuel U Eyesan SU, Abdulkareem FB: Fine needle aspiration cytology of bone tumours- the experiencefrom the National Orthopaedic and Lagos University Teaching Hospitals, Lagos, Nigeria. CytoJournal 2006;3:16.
- Aly AM, Shaaban HM, Abou-Sinna I: Accuracy of fine needle aspiration cytology in the diagnosis of bone lesions with radiological assistance: Experience from the National Cancer Institute, Cairo University, Egypt. The Egyptian Journal of Radiology and Nuclear Medicine 2014;45:127–
- Jain M, Aiyer HM, Singh M, Narula M: Fine-needle aspiration diagnosis of giant cell tumour of bone presenting at unusual sites. Diagn Cytopathol. 2002;27:375-8.
How to Cite This Article
Vancouver
Hassan MJ, Khan S, Ahmad N, Akhter K. Role of fine needle aspiration cytology in diagnosis of various giant cell lesions of bone and its Histopathological correlation [Internet]. Indian J Pathol Oncol. 2016 [cited 2025 Sep 30];3(4):582-586. Available from: https://doi.org/
APA
Hassan, M. J., Khan, S., Ahmad, N., Akhter, K. (2016). Role of fine needle aspiration cytology in diagnosis of various giant cell lesions of bone and its Histopathological correlation. Indian J Pathol Oncol, 3(4), 582-586. https://doi.org/
MLA
Hassan, Mohammad Jaseem, Khan, Sabina, Ahmad, Nihal, Akhter, Kafil. "Role of fine needle aspiration cytology in diagnosis of various giant cell lesions of bone and its Histopathological correlation." Indian J Pathol Oncol, vol. 3, no. 4, 2016, pp. 582-586. https://doi.org/
Chicago
Hassan, M. J., Khan, S., Ahmad, N., Akhter, K.. "Role of fine needle aspiration cytology in diagnosis of various giant cell lesions of bone and its Histopathological correlation." Indian J Pathol Oncol 3, no. 4 (2016): 582-586. https://doi.org/