- Visibility 667 Views
- Downloads 672 Downloads
- Permissions
- DOI 10.18231/j.ijpo.2025.045
-
CrossMark
- Citation
A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia
Non-seminomatous germ cell tumors have been not more frequently linked to Acute Myeloid Leukemia (AML) (M7), a rare form of primary AML. Review of literature regarding the case has shown that there were 26 case reports of concomitant mediastinal non seminomatous germ cell tumors in the last seven decades. However not a single case of testicular germ cell tumour with acute myeloid leukemia was reported making this case report rare of its kind. Here, we described a rare instance of dual malignancy that was treated at our center, synchronous testicular non- seminomatous germ cell tumour and acute myeloid leukemia (M7), which led to the patient's death as he was unable to tolerate chemotherapy.
Keywords: Synchronous testicular, Non-seminomatous germ cell tumour (NSGCT), Acute myeloid leukemia, Chemotherapy.
References
- Patel SR, Richardson RL, Kyols L. Synchronous and methacronous bilateral testicular tumors: Mayo Clinic experience. Cancer. 1990;65(1):1– 4.
- Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G. Hematologic neoplasia associated with primary mediastinal germ-cell tumors. N Engl J Med. 1990;322(20):1425-9.
- Christodoulou J, Schoch C, Schnittger S, Haferlach T. Myelodysplastic syndrome (RARS) with +i(12p) abnormality in a patient 10 months after diagnosis and successful treatment of a mediastinal germ cell tumor (MGCT). Ann Hematol. 2004;83(6):386–9.
- Berruti A, Pazè E, Fara E, Gorzegno G, Dogliotti L. Acute myeloblastic leukemia associated with mediastinal nonseminomatous germ cell tumors. Report on two cases. Tumori. 1995;81(4):299–301.
- Solé F, Bosch F, Woessner S, Pérez-Losada A, Cervantes F, Montserrat E, et al. Refractory anemia with excess of blasts and isochromosome 12p in a patient with primary mediastinal germ-cell tumor. Cancer Genet Cytogenet. 1994;77(2):111–3.
- Chariot P, Monnet I, Gaulard P, Abd-Alsamad I, Ruffié P, De Cremoux H. Systemic mastocytosis following mediastinal germ cell tumor: an association confirmed. Hum Pathol. 1993;24(1):111–2.
- Koo CH, Reifel J, Kogut N, Cove JK, Rappaport H. True histiocytic malignancy associated with a malignant teratoma in a patient with 46XY gonadal dysgenesis. Am J Surg Pathol. 1992;16(2):175–83.
- Downie PA, Vogelzang NJ, Moldwin RL, Le Beau MM, Anastasi J, Allen RJ, et al. Establishment of a leukemia cell line with i(12p) from a patient with a mediastinal germ cell tumor and acute lymphoblastic leukemia. Cancer Res. 1994;54(18):4999-5004.
- Larsen M, Evans WK, Shepherd FA, Phillips MJ, Bailey D, Messner H. Acute lymphoblastic leukemia. Possible origin from a mediastinal germ cell tumor. Cancer. 1984;53(3):441–4.
- Chowdhary GS, Jhala MD. A rare case of mediastinal nonseminomatous germ cell tumor with acute Megakaryocytic Leukemia. J Mar Med Soc. 2017;19(1):55–7.
- Bokemeyer C, Nichols CR, Droz JP, Schmoll HJ, Horwich A, Gerl A, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol. 2002;20(7):1864–73.
- Hartmann JT, Nichols CR, Droz JP, Horwich A, Gerl A, Fossa SD, et al. Hematologic disorders associated with primary mediastinal nonseminomatous germ cell tumors. J Natl Cancer Inst. 2000;92(1):54–61.
- Oshrine BR, Olsen MN, Heneghan M, Wertheim G, Daber R, Wilmoth DM, et al. Acquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor. Cancer Genet. 2014;207(4):153–9.
- Hiramatsu H, Morishima T, Nakanishi H, Mizushima Y, Miyazaki M, Matsubara H, et al. Successful treatment of a patient with Klinefelter's syndrome complicated by mediastinal germ cell tumor and AML(M7). Bone Marrow Transplant. 2008;41(10):907–8.
- Blandino G, Di Agostino S. New therapeutic strategies to treat human cancers expressing mutant p53 proteins. J Exp Clin Cancer Res. 2018;37(1):30.
- Dillon LM, Miller TW. Therapeutic targeting of cancers with loss of PTEN function. Curr Drug Targets. 2014;15(1):65–79.
- Shah S, Ward JE, Bao R, Hall CR, Brockstein BE, Luke JJ. Clinical Response of a Patient to Anti-PD-1 Immunotherapy and the Immune Landscape of Testicular Germ Cell Tumors. Cancer Immunol Res. 2016;4(11):903–9.
- Msaouel P, Bilen MA, Zhang M, Campbell M, Wang J, Tu S-M. Recent developments in the management of germ cell tumors. Curr Opin Oncol. 2017;29(3):172–8.
- Akizuki K, Sekine M, Kogure Y, Kameda T, Shide K, Koya J, et al. TP53 and PTEN mutations were shared in concurrent germ cell tumor and acute megakaryoblastic leukemia. BMC Cancer. 2020;20(1):5.
- Gibas Z, Prout GR, Pontes JE, Sandberg AA. Chromosome changes in germ cell tumors of the testis. Cancer Genet Cytogenet. 1986;19(34):245–52.
- Heinonen K, Rao PN, Slack JL, Cruz J, Bloomfield CD, Mrozek K. Isochromosome 12p in two cases of acute myeloid leukaemia without evidence of germ cell tumour. Br J Haematol. 1996;93(3):677–80.
How to Cite This Article
Vancouver
Ladda PS, Mundada M, Ahmed F, Rajappa SJ. A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia [Internet]. Indian J Pathol Oncol. 2025 [cited 2025 Oct 16];12(2):224-227. Available from: https://doi.org/10.18231/j.ijpo.2025.045
APA
Ladda, P. S., Mundada, M., Ahmed, F., Rajappa, S. J. (2025). A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia. Indian J Pathol Oncol, 12(2), 224-227. https://doi.org/10.18231/j.ijpo.2025.045
MLA
Ladda, Pallavi S, Mundada, Manasi, Ahmed, Faiq, Rajappa, Senthil J. "A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia." Indian J Pathol Oncol, vol. 12, no. 2, 2025, pp. 224-227. https://doi.org/10.18231/j.ijpo.2025.045
Chicago
Ladda, P. S., Mundada, M., Ahmed, F., Rajappa, S. J.. "A rare case report of 27-year-old young male with synchronous testicular non seminomatous germ cell tumour and acute myeloid leukemia." Indian J Pathol Oncol 12, no. 2 (2025): 224-227. https://doi.org/10.18231/j.ijpo.2025.045