Background: Gall bladder carcinoma is the most common gastrointestinal cancer in Indian having poor prognosis due to advanced stage at presentation. There is marked geographical variation in the prevalence of GB carcinoma worldwide .Among the developed countries it is more prevalent in South American and Eastern European countries. The highest incidence of gallbladder carcinoma is found along the Gangetic plains of India.
Aim and Objective: The present study aim to correlate morphological changes with clinicopathological parameters (age of patients, number of stones and gallbladder wall thickness) and demographic parameters.
Materials and Methods: In our study 1500 cases of cholecystectomy specimens with stones were reviewed in span of 18 months. H and E sections were studied.
Result: 287/1500 cholecystectomy specimens precursor lesions were identified (122 hyperplasia, 135 metaplasia and 30 dysplasia).The age of the patients ranged between 18 years to 60 years. The wall thickness > 3 mm in 18%, 24% and 26% cases of hyperplasia, metaplasia and dysplasia respectively. The gallbladder specimens from all 287 patients with hyperplasia, metaplasia and dysplasia had either single or multiple stones. Multiple stones were found in 85%, 80% and 80% cases of hyperplasia, metaplasia and dysplasia respectively. Three types of stones were found (pigmented, cholesterol and mixed stones).
Conclusion: On comparing the GB wall thickness, number and types of gall stones in various precursor lesions there was no significant correlation suggesting that these parameters have no role in GB carcinogenesis. However, the duration of stone might play an important role in GB carcinogenesis as suggested in earlier studies.
Keywords: Metaplasia, Dysplasia, Hyperplasia, Carcinoma.
