- Visibility 775 Views
- Downloads 669 Downloads
- Permissions
- DOI 10.18231/j.ijpo.2025.030
-
CrossMark
Clinico pathological spectrum of bone lesions in a five year study in a tertiary care centre
- Author Details:
-
Meera Bhanu *
-
Sateesh S Chavan
-
Kanchana Jayaram
-
Amaya Bhaskaran
-
Sunita Vernekar
Meera Bhanu *
Sateesh S Chavan
Kanchana Jayaram
Amaya Bhaskaran
Sunita Vernekar
Background: Bone lesions exhibit a wide range of characteristics and their trends vary according to age, clinical features, and the frequency of the different histological types. The objective of our study is to investigate the clinical and pathological spectrum of bone lesions, focusing on their incidence, age, sex, anatomical distribution, and histomorphological features. This study provides an opportunity to uncover new insights regarding the incidence and distribution of bone lesions.
Objectives: To study the clinical and pathological spectrum of bone lesions over a period of five years in a tertiary care centre in North Karnataka.
Materials and Methods: Bone biopsies and resection specimens received from January 2019 to December 2023 at the department of Pathology, Karnataka Medical College and research institute, Hubli were included in the study.
Results: During a period of five years, a total of 185 cases of bone specimen were received, of which neoplastic lesions (n = 115, 62.2%) were more common than non-neoplastic lesions (n = 70, 37.8%). In the neoplastic lesions, majority of the tumours were benign, (69 cases, 60.0%), followed by malignant tumours (24 cases, 20.9%) and least common were intermediate grade tumours (22 cases, 19.1%). Chronic osteomyelitis was the most common histological diagnosis (23.2%) followed by Osteochondroma (18.9%). Osteosarcoma was the most common malignant bone tumour (7.0%).
Conclusion: The present study shows the clinicopathological spectrum of bone lesions. 23 different entities of bone lesions were reported in the pathology section of our college during a period of five years. Neoplastic lesions were more common. But chronic osteomyelitis was the single most common bone lesion followed by osteochondroma. Osteosarcoma was the most common malignant neoplastic lesion.
Keywords: Bone lesions, Histopathology, Osteochondroma, Giant cell tumour, Osteosarcoma.
References
- Rhutso Y, Laishram RS, Sharma LD, Debnath K. Histopathological evaluation of bone tumors in a tertiary care hospital in Manipur, India. J Med Soc. 2013;27(2):135–9.
- Deoghare SB, Prabhu MH, Ali SS, Inamdar SS. Histomorphological spectrum of bone lesions at tertiary care centre. Int J Life Sci Sci Res. 2017;3(3):980–5.
- Kokode D, Wilkinson A. A clinicopathological study of lesions of bone. Clin Diagn Pathol. 2019;3:1–5.
- Sajjanar AB, Rajagopal A, More SS. A histopathological study of bone lesions in a tertiary care hospital in Kolhapur. Int J Clin Diagn Pathol. 2019;2(2):419–22.
- Jain K, Sunila, Ravishankar R, Mruthyunjaya, Rupakumar CS, Gadiyar HB et al. Bone tumors in a tertiary care hospital of south India: A review 117 cases. Indian J Med Paediatr Oncol. 2011;32(2):82–5
- Bamanikar SA, Pagaro PM, Kaur P, Chandanwale SS, Bamanikar A, Buch AC. Histopathological study of primary bone tumours and tumour-like lesions in a medical teaching hospital. J Krishna Inst Med Sci Univ. 2015;4(2):46–55.
- Chakravarthy A, Shetty JK, Kishan Prasad HL. Bone lesions: Benign, malignant and inflammatory; A Histopathological study. Int J Clin Diagn Pathol. 2020;3(3):74–78.
- Karia KM, Iqbal MB, Patil AA, Agrawal NS, Kumar H. Study to Correlate the Histopathological Spectrum of Bone Lesions with Demographic Profile of Patients in a Tertiary Care Institution. Clin Cancer Investig J. 2017;6:254–7.
- Abdulkareem FB, Eyesan SU, Akinde OR, Ezembakwe ME, Nnodu OE. Pathological study of bone tumours at the National Orthopaedic Hospital, Lagos, Nigeria. West Afr J Med. 2007;26(4):306–11.
- Kethireddy S, Raghu K, Chandra Sekhar KP, Babu YS, Dash M. Histopathological evaluation of neoplastic and non-neoplastic bone tumours in a teaching hospital. J Evol Med Dent Sci. 2016;5(86):6371–4.
- Baena-Ocampo L. Ramirez-perez E, linares-gonzalez LM and delgado-chavez R. Epidemiology of bone tumors in Mexico city: retrospective clinicopathologic study of 566 patients at a referral institution. Ann Diagn Pathol. 2009;13(1):16–21.
- Patel D, Patel P, Gandhi T, Patel N, Patwa J. Clinicopathological study of bone lesions in tertiary care center–A review of 80 cases. IJAR. 2015;3:1267–72.
- Das PK, Dutta B, Musfique J, Das PP. Clinicopathological study of lesions of bone – a hospital-based study. J Evid Based Med Healthc. 2020;7(39):2161–4.
- Kaushik B, Anand V, Paritosh P, Patel D. A clinicopathological study of lesions of bone. Asian J Pharm Clin Res. 2023;16(12):216–22.
- Ragini K, Shankar K, Chaudhary A, Debarshi J. Histopathological study of bone lesions at darbhanga medical college, Laheriasarai, Bihar. Int J Scientific Res. 2021;10(1)1–3.
- Manjani S, Arulparithi CS, Viswanathan P, Harke AB, Karthik S, Shobana B, et al. Histopathological Spectrum of Bone Lesions in a Tertiary Care Hospital. Saudi J Pathol Microbiol, 2021;6(1):5–7.
- George M, Shwetha J. Histopathological Study of Bone Lesions. Int J Curr Adv Res. 2017;6(9):6330–3.
- Gayathri T, Shashikala V, Sody R. Spectrum of tumour and tumour- like lesions of bone in a Tertiary Care Hospital in North Karnataka, India. Indian J Pathol Oncol. 2018;5(1):75–80
- Obalum DC, Giwa SO, Banjo AF, Akinsulire AT. Primary bone tumours in a tertiary hospital in Nigeria: 25-year review. Niger J Clin Pract. 2009;12(2):169–72.
- Sugiyama H, Omonishi K, Yonehara S, Ozasa K, Kajihara H, Tsuya T, et al. Characteristics of benign and malignant bone tumors registered in the Hiroshima Tumor Tissue Registry, 1973-2012. JBJS Open Access. 2018;3(2):e0064.
- Blackwell JB, Curnow MN. Benign bone tumours in Western Australia, 1972- 1996. Pathology. 2007;39(6):567–74.
- Bahebeck J, Atangana R, Eyenga V, Pisoh A, Sando Z, Hoffmeyer P. Bone tumours in Cameroon: incidence, demography and histopathology. Int Orthop. 2003;27:315–7.
- Hasan FF, Mohammed HL. Comparison between benign and malignant primary bone tumors-a histopathological study of 119 cases. Al-Mustansiriyah J Sci. 2018;29(2):74–82.
- Sharma S, Mehta NP. Histopathological study of bone tumors. Int J Sci Res. 2015;4(12):1970–2.
- Shah SH, Muzaffar S, Soomro IN, Pervez S, Hasan SH. Clinico- morphological pattern and frequency of bone cancer. J Pak Med Assoc. 1999;49(5):110.
- Ahmad M, Ghani A, Mansoor AD, Khan AH. Pattern of malignant bone tumour in northern areas of Pakistan. J Pak Med Assoc. 1994;44(9):203–5.
- Gayathri T, Shashikala V, Sody R. Histopathological Study of Malignant Bone Tumours in a Tertiary Care Centre in Karnataka, India. Indian J Pathol Res Pract. 2017;6(4):875–79.
- Nayar M, Chandra M, Saxena HM, Dass GC. Bone tumors and tumour--like conditions--a retrospective study. Indian J Cancer. 1979;16(2):18–25.
- Chitale AR, Jambhekar NA. Report of bone registry, 1970-1982 (a twelve year study). Indian J Pathol Microbiol. 1987;30(2):201–18.