BRCA1 expression and its association with histological typing, grade, ER, PR, HER2 in carcinoma of breast

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Original Article

Author Details : Kush Juneja, Anupam Varshney*, Rajnish Kumar, Mamta Singla, Purva Sharma

Volume : 6, Issue : 3, Year : 2019

Article Page : 376-380

https://doi.org/10.18231/j.ijpo.2019.073

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Abstract

Breast cancer is the most commonly diagnosed cancer in female worldwide. BRCA 1 is located predominantly in nucleus. BRCA 1 is associated with breast cancer.
Materials and Methods: This was retroprospective study, 50 known cases of breast carcinoma were analysed in Muzaffarnagar Medical College, Muzaffarnagar.
Observation and Results: The age range of patients was from 28-70 years and mean age of patients was 50.24 years. Majority of breast carcinoma were above 45 years of age (64%) and of upper outer quadrant (52%) and of grade II (48%). Invasive carcinoma of no special type (NST) formed the majority of cases (82%) followed by Invasive lobular carcinoma (6%). Altered BRCA 1 expression was seen in ER, PR and HER 2 negative cases.
Conclusions: Invasive Carcinoma of no special type was the commonest morphological type. Majority of cases of breast carcinoma were of grade II.

Keywords: BRCA 1, Invasive Carcinoma NST, ER, PR, Her 2 neu, IHC.

How to cite : Juneja K, Varshney A, Kumar R, Singla M, Sharma P, BRCA1 expression and its association with histological typing, grade, ER, PR, HER2 in carcinoma of breast. Indian J Pathol Oncol 2019;6(3):376-380

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