Histopathologic spectrum of adrenal lesions

---

Original Article

Author Details : Saritha Karre, Amrutha Gorva, Chandrakumar Shanmugam, V. D. Praveen Kumar Gorrela, Satyanarayana Vee

Volume : 5, Issue : 3, Year : 2018

Article Page : 463-469

https://doi.org/10.18231/2394-6792.2018.0090

Suggest article by email

Get Permission

---

Abstract

Introduction: The bipartite adrenal gland has tumors arising from cortex, medulla or as metastasis from extra-adrenal sites. Distinguishing benign from malignant types is a challenging task for pathologists, this study gives an insight into adrenal lesions with their histopathological and immunohistochemical findings and its role in categorizing these tumors to aid in their diagnosis and proper management.
Aim: To study the Histopathological patterns of adrenal lesions with clinical correlation.
Materials and Methods: In a five year period10 surgical specimens of adrenal tumors were resected and studied between July 2010 to June 2015 at Kamineni Institute of Medical Sciences, Narketpally and King Koti. Tissues were processed and stained sections were studied for histopathological patterns and IHC markers used were vimentin, synaptophysin, NSE, chromogranin immunohistochemistry was done wherever necessary and the markers used were vimentin, synaptophysin, NSE, chromogranin.
Result: Out of ten adrenal lesions we have studied, two cases were adrenal cysts,¹ three were cortical adenoma, one case is Adrenocortical carcinoma-positive for synaptophysin, vimentin, two cases were neuroblastoma-positive for NSE, chromogranin and synaptophysin and two cases are pheochromocytoma - positive for chromogranin.
Conclusion: Pathological evaluation and immunohistochemical profiling has got important role in categorizing adrenal tumors along with clinical, radio logical and biochemical inputs and their subsequent management.

Keywords: Adrenal cyst, Adrenal adenoma and Carcinoma (Weiss system), Neuroblastoma, Pheochromocytoma.

How to cite : Karre S, Gorva A, Shanmugam C, Gorrela V D P K, Vee S, Histopathologic spectrum of adrenal lesions. Indian J Pathol Oncol 2018;5(3):463-469

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.