Clinicopathological study of neoplastic and non-neoplastic lesions of prostate- two years study

---

Original Article

Author Details : SD Birare, SK Mahule, KT Dalve, NR Patil, NV Naigaonkar

Volume : 4, Issue : 4, Year : 2017

Article Page : 622-628

Suggest article by email

Get Permission

---

Abstract

Introduction: Among the cancer related deaths in men, prostatic cancer is the second most common to lung cancer. Important cause for prostatic morbidity and mortality includes inflammation, benign nodular enlargement and tumors. Histopathological diagnosis and grading plays a definitive role in the management of prostatic cancer. The current study aims at analyzing clinicopathological features of various neoplastic and non-neoplastic lesions of the prostate.
Materials and Method: The present study included 158 prostatic specimens, which comprises of 157 TURP chips, and 1 prostatectomy specimen. The results were grouped into non-neoplastic and neoplastic lesions. The cases of prostatic adenocarcinoma were graded using Gleason microscopic grading.
Results: Out of 158 prostatic specimens studied; 145 were benign lesions, 4 were premalignant and 9 were malignant lesions. Among benign lesions nodular hyperplasia without prostatitis was the most common. The cancer detection rate with prostatic volume < 40 ml was higher than with >40 ml. Most malignant prostatic lesions showed marked elevation in serum PSA levels (>20 ng/ml). Among the malignant lesions, commonest lesion was prostatic adenocarcinoma.
Discussion: Since low-grade lesions are usually asymptomatic, awareness of serum PSA level estimation, digital rectal examination should be done among elderly males who are prone for malignancy. Male individuals with a positive family history for prostatic carcinoma must undergo relevant screening test.

Keywords: Prostate, Hyperplasia, Adenocarcinoma, PSA, Gleason score

How to cite : Birare S, Mahule S, Dalve K, Patil N, Naigaonkar N, Clinicopathological study of neoplastic and non-neoplastic lesions of prostate- two years study. Indian J Pathol Oncol 2017;4(4):622-628

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.