Association of Hypertension and Diabetes Mellitus with non-Hodgkin lymphoma - A hospital based study of 410 cases

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Original Article

Author Details : Vijayshree Shivappa Neeravari, Doddappa Malleshappa Bannigidad, Lakshmi Rao

Volume : 3, Issue : 4, Year : 2016

Article Page : 696-700

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Abstract

Several studies have found increased association of Diabetes Mellitus(DM) and Hypertension(HTN) in patients with non-Hodgkin lymphoma (NHL). We determined association of Diabetes Mellitus and Hypertension in 410 Non-Hodgkin lymphoma (NHL) patients diagnosed and treated in our institution.
Results: 8.5% of NHL cases were associated with diabetes Mellitus. Among NHL patients with diabetes Nodal NHL were commoner than the Extranodal NHL. The most common subtype was Diffuse Large B Cell Lymphoma (DLBCL) followed by Follicular lymphoma (FL) with a frequency of 57.14% and 17.14% respectively.
Hypertension was associated with 9.5% of NHL cases. Among the hypertensive patients, Extranodal NHL were more common with DLBCL being the most commonest subtype, followed by follicular lymphoma with a frequency of 56.4% and 20.5% respectively.
Conclusion: Diabetes Mellitus and Hypertension are associated with development of NHL either directly or due to drugs used in the treatment. Further studies are required to identify the specific drugs involved in the development of NHL especially in the Asian populations where prevalence of diabetes and Hypertension has increased in the recent years.

Keywords: Hypertension, Diabetes Mellitus, Non-Hodgkin lymphoma

How to cite : Neeravari V S, Bannigidad D M, Rao L, Association of Hypertension and Diabetes Mellitus with non-Hodgkin lymphoma - A hospital based study of 410 cases. Indian J Pathol Oncol 2016;3(4):696-700

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