Clinico-pathological study of breast carcinoma with correlation to hormone receptor status & HER2/neu

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Original Article

Author Details : Vedashree MK, V. Rajalakshmi

Volume : 3, Issue : 4, Year : 2016

Article Page : 690-695

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Abstract

Carcinoma of the breast is the most common malignant tumor and the most common cause of death from carcinoma in females all over the world. In recent years, interest in prognostic factors has been stimulated by the success of systemic adjuvant therapy for early stage of breast carcinoma. The important pathological prognostic factors in invasive breast carcinoma include patient’s age, tumor size, lymph node metastasis, nuclear grade, histological grade, histological type, hormone receptor status & HER2/neu. Tumors that express both Estrogen Receptor(ER) and Progesterone Receptor(PR) have the greatest benefit from hormonal therapy. HER2/neu has its role as a prognostic indicator and as a predictor of response to Trastuzumab (Herceptin) therapy in breast cancer patients. The study was conducted in Department of Pathology, Kilpauk Medical College, Chennai from July 2008 to August 2011. 73 cases of mastectomy specimens were received and clinical staging, histological grading and NPI score were analysed for these cases. 55 cases were selected at random and ER, PR & HER2/neu status was analysed. Greater than 80% of the cases were 40 years and above and majority (56.2%) were postmenopausal. Maximum number of cases (65.8%) were stage 2 and grade 2(72.6%).
ER was positive in 30.9%, PR in 25.5%, HER2/neu in 30.9%. The prevalence of hormone receptor positivity was less & HER2/neu positivity was higher which was in concordance with the studies conducted in Asian population compared with western world. There was a statistically significant association between the two hormone receptor expressions but not with other prognostic factors.

Keywords: Breast carcinoma, Clinical staging, Histological grading, Hormone receptor status, HER2/neu

How to cite : Vedashree Mk, Rajalakshmi V, Clinico-pathological study of breast carcinoma with correlation to hormone receptor status & HER2/neu. Indian J Pathol Oncol 2016;3(4):690-695

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