PATHOPHYSIOLOGY OF FIBROIDS

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Review Article

Author Details : Harpreet Kaur, Aayushi Gulati

Volume : 1, Issue : 1, Year : 2014

Article Page : 14-17

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Abstract

Fibroids are the commonest benign tumors of female genital tract. They are mainly composed of smooth muscle & fibrous connective tissue. Etiopathogenesis of fibroids is linked to hormones (estrogen & progesterone), genetic factors and some growth factors. Estrogen is the main predisposing factor-there is increased density of estrogen in fibroids compared to normal myometrium and increased concentration of aromatase leading to high local estrogen levels. The growth promoting effect of estrogen & progesterone has been shown to be mediated through local production of growth factors.

 

Key-words: fibroids, pathophysiology, growth factors.

How to cite : Kaur H, Gulati A, PATHOPHYSIOLOGY OF FIBROIDS. Indian J Pathol Oncol 2014;1(1):14-17

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