Analysis of clinical and histopathological differences between right and left sided colon cancers

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Original Article

Author Details : Avantika Kailu, Bawana Raina*, Chakshu Mahajan

Volume : 11, Issue : 4, Year : 2024

Article Page : 352-356

https://doi.org/10.18231/j.ijpo.2024.077

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Abstract

Background: Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) exhibit distinct clinicopathological characteristics, which may influence their diagnosis, treatment, and prognosis. Understanding these differences is crucial for optimizing patient care and outcomes.
Aim and Objective: This study aimed to analyse and compare the clinical and histopathological features of RCC and LCC in a cohort of 80 patients, focusing on demographic characteristics, clinical presentation and tumor pathology.
Materials and Methods: A retrospective analysis was conducted on 80 patients diagnosed with colon cancer, divided equally between RCC (n=40) and LCC (n=40). Data on demographic characteristics, clinical presentation, histologic type, tumor size, histologic grade, tumor stage, lymphovascular invasion, and perineural invasion were collected. Statistical analysis was performed using appropriate tests, with a significance level set at p < 0> Results: The mean age of RCC patients was significantly higher than that of LCC patients (68 ± 8 years vs. 64 ± 7 years, p = 0.02). RCC patients more commonly presented with anemia (50% vs. 20%, p = 0.006) and weight loss (40% vs. 15%, p = 0.01), while LCC patients were more likely to report changes in bowel habits (50% vs. 15%, p = 0.001) and rectal bleeding (40% vs. 10%, p = 0.002). Histologic type distribution was similar between RCC and LCC, with adenocarcinoma being the most common subtype in both groups.RCC tumors were larger on average (6.2 ± 1.4 cm vs. 4.5 ± 1.1 cm, p = 0.001) and more likely to be high-grade (40% vs. 20%, p = 0.04).
Conclusion: This study highlights significant differences between RCC and LCC in terms of age, clinical presentation, tumor size, and histologic grade. RCC is associated with older age, larger and higher-grade tumors, and a higher incidence of anemia and weight loss, while LCC more frequently presents with changes in bowel habits and rectal bleeding.
 

Keywords: Right sided colon cancer (RCC), Left sided colon cancer (LCC), Histopathological characteristics, Adenocarcinoma, Lymphovascular invasion, Perineural invasion.

How to cite : Kailu A, Raina B, Mahajan C, Analysis of clinical and histopathological differences between right and left sided colon cancers. Indian J Pathol Oncol 2024;11(4):352-356

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