A rare case of pineoblastoma – Case report

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Case Report

Author Details : Shivani Kanjibhai Patel, Preeti Jhaveri*, Minesh B Gandhi, Cherry K Shah

Volume : 11, Issue : 2, Year : 2024

Article Page : 191-194

https://doi.org/10.18231/j.ijpo.2024.041

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Abstract

Pineoblastoma is a very rare and aggressive malignant tumor of pineal gland. We report a case of 12-year-old male patient presented to S.V.P. tertiary care hospital with complain of progressive loss of vision in both eyes with nausea and headache. On examination bilateral upward gaze palsy was present. The magnetic resonance imaging report revealed possibility of pineal Germinoma. The patient underwent ventriculoperitoneal shunt insertion surgery for obstructive hydrocephalus and suboccipital craniectomy for tumor resection. The Histopathological examination report stated the tumor as Pineoblastoma, Grade IV. Immunohistochemistry studies were positive for synaptophysin and Integrase interactor-1 (INI-1) markers with high ki-67 labelling index and negative for CD-117 and Glial fibrillary acid protein (GFAP) markers. Microscopic and Immuno histochemisty findings are important to differentiate pineoblastoma from other pineal region tumors.
 

Keywords: Pineoblastoma, Hydrocephalus, Synaptophysin, Pineal gland.

How to cite : Patel S K, Jhaveri P, Gandhi M B, Shah C K, A rare case of pineoblastoma – Case report. Indian J Pathol Oncol 2024;11(2):191-194

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