Comprehensive overview: Car T cell therapy

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Review Article

Author Details : Bodhimala Nagrale*, Jagruti Koshti, Ashwini Chavan, Hemant Raut, Amit Kakad

Volume : 11, Issue : 2, Year : 2024

Article Page : 100-107

https://doi.org/10.18231/j.ijpo.2024.025

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Abstract

CAR T cell therapy is now-a-days employed in treating various varieties of cancer like that Blood malignancies, solid tumour, peptic cancer etc. Chimeric antigen receptor are created by taking patient T cells and reprogramming them in a lab to develop a protein or surface that binds to and recognizes particular antigens or protein molecules found on the outer layer of cancer cells. In CAR there are four basic parts named as 1) an antigen-binding domain found outside of the cell, 2) a hinge area, 3) A domain across membranes, and 4) any number of signaling regions within cells. CARs are modular synthetic receptors. There are three generations of CAR i.e. 1) 1st generation CAR 2) 2nd generation CAR 3) 3rd generation CAR. CAR T cell therapy is also used in lymphoma, myeloma, in solid tumour such as breast cancer. Recently ROR-1 CAR T cell is used which support death of tumour cell.
 

Keywords: Blood malignancies, Chimeric antigen receptor (CAR)- T cell, Immunotherapy, Tumour cell.

How to cite : Nagrale B, Koshti J, Chavan A, Raut H, Kakad A, Comprehensive overview: Car T cell therapy. Indian J Pathol Oncol 2024;11(2):100-107

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