Peripheral blood smear diagnosis of invasive candidiasis in a patient of myelodysplastic syndrome/myeloproliferative neoplasm treated with hypomethylating agent: A case report

---

Case Report

Author Details : Rupali Shripal Parikh, Paresh R Marathe, Akanksha Sanjay Fokmare*, Siddesh Tribhuvan Gupta

Volume : 11, Issue : 1, Year : 2024

Article Page : 95-97

https://doi.org/10.18231/j.ijpo.2024.023

Suggest article by email

Get Permission

---

Abstract

Patients with haematological malignancies undergoing treatment with hypomethylating agents are predisposed to opportunistic infections, including Candidiasis. We present the case of a 73-year-old female patient diagnosed with Myelodysplastic/Myeloproliferative neoplasms who was receiving a hypomethylating agent as part of her treatment regimen. During the course of her treatment, peripheral blood smear examination revealed the presence of budding yeast cells, consistent with Candida species. Subsequent culture confirmed the diagnosis of Candidiasis.The development of Candidiasis in patients with haematological malignancies receiving hypomethylating agents poses a significant clinical challenge due to overlapping symptoms with other infections and chemotherapy-induced myelosuppression. Peripheral smear examination serves as a rapid and cost-effective adjunctive diagnostic tool for the early detection of Candidiasis in these patients. Timely detection of Candidiasis in this population is critical for appropriate management and improved outcomes.
 

Keywords: Candidemia, Haematological malignancies, Hypomethylating agents, Myelodysplastic/Myeloproliferative neoplasms, Peripheral smear.

How to cite : Parikh R S, Marathe P R, Fokmare A S, Gupta S T, Peripheral blood smear diagnosis of invasive candidiasis in a patient of myelodysplastic syndrome/myeloproliferative neoplasm treated with hypomethylating agent: A case report. Indian J Pathol Oncol 2024;11(1):95-97

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.