Clinicopathological and flowcytometric analysis of platelet function in patients presenting with thrombocytopenia

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Original Article

Author Details : Sandeep Bhandari, Meena Singrol, Lal Panay Singh*, Priyanka Verma

Volume : 10, Issue : 4, Year : 2023

Article Page : 362-365

https://doi.org/10.18231/j.ijpo.2023.081

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Abstract

Background: Platelet function disorders are highly heterogeneous; those may be inherited/ acquired. Patients with these may have inadequate platelet count with impaired function, but may also have both. Early detection of platelet dysfunction also helps in better patient management and improve outcome.
Material and Methods: Prospective study done in 50 cases, Patient’s details history of thrombocytopenia. Complete blood count with peripheral smear is done and various parameters are analysed with respect to the platelet count, PDW, P-LCR. On EDTA preserved blood sample four monoclonal antibodies CD41, CD42b, CD61 and CD62p are applied and analysed by flow cytometer.
Results: In 50 thrombocytopenia cases out of which 06(12%) were immunological thrombocytopenia & 44 (88%) were non-immunological thrombocytopenia.

Keywords: Immunological thrombocytopenia, Flow­ cytometry, Platelets, Monoclonal antibodies.

How to cite : Bhandari S, Singrol M, Singh L P, Verma P, Clinicopathological and flowcytometric analysis of platelet function in patients presenting with thrombocytopenia. Indian J Pathol Oncol 2023;10(4):362-365

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