Accuracy of different cytoarchitectural features in the diagnosis of papillary thyroid carcinoma by fine needle aspiration

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Original Article

Author Details : I W G A L Malhasi*, C S Fernando, MVC de Silva

Volume : 10, Issue : 1, Year : 2023

Article Page : 15-28

https://doi.org/10.18231/j.ijpo.2023.004

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Abstract

Introduction and Objectives: Fine needle aspiration (FNA) has about 90% diagnostic accuracy for papillary thyroid carcinoma (PTC) in an adequate sample. Ignorance of relative significance of individual cytologic features may lead to misdiagnosis due to reliance on a single or few features. Our objective was to determine the usefulness of individual and most appropriate combined cytologic features, for diagnosis of PTC.
Materials and Methods: H&E stained FNA smears of fifty cases each, of consecutive histologically confirmed PTC and benign thyroid cases (controls), reported over 3 years, were retrieved from the files. A total of 31 architectural, cytological and background features were assessed, blind to the final diagnosis and compared amongst the two groups. The statistical significance (p<0> Discussion: Twenty features were found to be statistically significant. Fourteen highly significant (p<0 p=0.000> Conclusion: Using correct combination of cytologic features will increase accuracy of FNA diagnosis of PTC.
 

Keywords: Fine needle aspiration, Papillary thyroid carcinoma, Cytologic.

How to cite : Malhasi I W G A L, Fernando C S, Silva M D, Accuracy of different cytoarchitectural features in the diagnosis of papillary thyroid carcinoma by fine needle aspiration. Indian J Pathol Oncol 2023;10(1):15-28

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