Algorithmic approach of immunohistochemistry in metastatic carcinoma of unknown primary site

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Editorial

Author Details : Banushree C S*

Volume : 9, Issue : 3, Year : 2022

Article Page : 206-207

https://doi.org/10.18231/j.ijpo.2022.050

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Abstract

Cancers of unknown primary site (CUPs) are histologically confirmed metastatic carcinoma for which primary site cannot be identified after standard diagnostic approach. It comprises 3-4% of all malignant neoplasms. The broad tumour type for CUPs is carcinoma. Metastatic tumours are more difficult to classify than primaries by Immunohistochemistry (IHC). Integration of morphology & IHC is the gold standard at diagnosing CUP. It is important to be aware of possible pitfalls of IHC and pay attention to correct interpretation. One should have a working algorithmic approach to identifying and classifying CUPs.

Keywords: Malignant neoplasm, Immunohistochemistry, Metastatic carcinoma, Cytokeratin.

How to cite : Banushree C S*, Algorithmic approach of immunohistochemistry in metastatic carcinoma of unknown primary site. Indian J Pathol Oncol 2022;9(3):206-207

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