Histopathological study of gastric carcinoma with associated precursor lesions

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Original Article

Author Details : Manasa G C, Sunila, Manjunath GV

Volume : 3, Issue : 1, Year : 2016

Article Page : 26-31

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Abstract

Introduction: Gastric carcinoma is the most important and the most common of malignant tumours of stomach. Helicobacter pylori (H. Pylori) have been implicated as an important etiologic factor in gastric carcinoma through its role in the development of chronic gastritis. The study of gastric carcinoma with associated precursor lesion in various studies has shown variable results, our objective was to study histopathology of gastric carcinoma with regard to sex, age, anatomical location and morphology. And also to analyse association of gastric carcinoma with precursor lesions.
Materials and Methods: Over 83 endoscopic gastric biopsies and gastrectomy specimens received from department of surgery of our college during the period January 2009 to May 2011 were included in the study.
Results: Gastric carcinoma was most common in males and in the 7th decade. Most common histological type of tumor was intestinal type78.3%, seen in the 7thdecade followed by diffuse type 21.7% in the 6th decade. Precursor lesions were positive in out of 70cases of gastric carcinoma. And chronic atrophic gastritis was found in 42% of cases, dysplasia in33% and intestinal metaplasia in 36%. H. pylori were positive in 54.3% cases; among them 56.4% cases were intestinal type of carcinoma and 46.6% were diffuse type of carcinoma.
Conclusion: Although series was small our findings in this study were quite prominent and therefore indicate need for further studies of histological types its association with precursor lesion and H.pylori in larger population as there is high risk of gastric carcinoma in South India.

Key words: Gastric carcinoma, precursor lesions, Chronic atrophic gastritis, Intestinal metaplasia, Dysplasia, H.pylori.

How to cite : Manasa G C, Sunila, Manjunath Gv, Histopathological study of gastric carcinoma with associated precursor lesions. Indian J Pathol Oncol 2016;3(1):26-31

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