Extend of neuroendocrine differentiation in adenocarcinoma prostate needle biopsies

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Original Article

Author Details : Girija C*, Feroze M

Volume : 7, Issue : 4, Year : 2020

Article Page : 556-560

https://doi.org/10.18231/j.ijpo.2020.111

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Abstract

Neuroendocrine differentiation in prostatic adenocarcinoma is now one of the emerging prognostic factor
that determine treatment outcome. This study aims to identify the extent of neuroendocrine differentiation
amidst the tumour cells in adenocarcinoma prostate with the help of immunohistochemical marker,
Chromogranin A(CgA) and correlate with its Gleason score. A semiquantative scoring system was utilised
to estimate and quantify cells having neuroendocrine differentiation.
Results: Out of 40 cases of prostatic adenocarcinomas in needle core biopsies, 93% of patients with a
Gleason score >6 showed CgA positivity of more than 5% and 2cases (16.6%) having Gleason score 9
showed >50% of CgA positive cells in the tumour area.
Conclusion: Hence higher Gleason score correlated with higher degree of neuroendocrine differentiation
in our study.

Keywords: Adenocarcinoma prostate, Neuroendocrine differentiation.

How to cite : Girija C, Feroze M, Extend of neuroendocrine differentiation in adenocarcinoma prostate needle biopsies. Indian J Pathol Oncol 2020;7(4):556-560

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