Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis

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Original Article

Author Details : Bharat Jindal, Rajender Kumar Thakral, Alok Mohan*, Vaseem Ansari, Veena K Sharma

Volume : 7, Issue : 3, Year : 2020

Article Page : 378-383

https://doi.org/10.18231/j.ijpo.2020.076

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Abstract

Introduction: Breast cancer is the most frequently diagnosed cancer among females worldwide. p53
tumor suppressor gene regulates the cell cycle and DNA repair and its over-expression in breast cancer
is associated with a worse prognosis.
Objective: This study was done to correlate p53 over-expression with histopathological parameters such
as tumor size, tumor grade and lymph node metastasis in breast carcinoma.
Materials and Methods: This retroprospective study was conducted in a tertiary care centre, western U.P.
retroprospectively from July 2014 to June 2019. Immuno-histochemical evaluation of 50 histologically
confirmed cases of breast carcinoma was done.
Results: A total of 50 patients of breast carcinoma were analysed. Most common was Invasive carcinoma
of no special type (NST). Most common age group involved was 40-49 years and majority were of age
more than >45 years of age. Majority of breast carcinoma cases were of left breast and involving upper
outer quadrant. In majority of cases, the tumor size was of more than 2 to 5cms. Majority of cases of breast
carcinoma were of grade II according to Nottingham Modified Bloom Richardson System. More than half
of patients with lymph nodes showed metastatic deposits. Majority of cases were in moderate prognostic
index group. Out of 50 cases, 24(48%) cases showed p53 [removed]5%). High p53 [removed]>50%)
was seen in 8(16%) cases of breast carcinoma.
Conclusion: A statistically significant association was found between p53 expression, tumor size and
lymph node metastasis. No statistically significant association was found between p53 overexpression and
tumor grade. Overall, p53 overexpression was found to be poor prognostic factor and its detection may help
in risk catergorization and designing future target therapies.

Keywords: Breast cancer, Invasive carcinoma, Lymph node, p53 overexpression, Immuno-histochemistry.

How to cite : Jindal B , Thakral R K , Mohan A , Ansari V , Sharma V K , Role of p53 as a prognostic marker in breast carcinoma and its correlation with tumor size, tumor grade and lymph node metastasis. Indian J Pathol Oncol 2020;7(3):378-383

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