Vascular endothelial growth factor –A (VEGF-A) expression as a prognostic factor in breast cancer

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Original Article

Author Details : Lepakshi K, Usharani Rathnam*, P P Bapsy

Volume : 7, Issue : 1, Year : 2020

Article Page : 94-98

https://doi.org/10.18231/j.ijpo.2020.018

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Abstract

Objective: To assess the expression of VEGF-A in breast cancer patient and to find an association between
VEGF- A overexpression and the clinicopathologic features.
Materials and Methods: The study was conducted from January 2010 through 2016. Formalin-fixed,
paraffin-embedded blocks from 64 patients with breast cancer were included in this study. S treptavidinbiotin
method was employed for immunohistochemical detection of VEGF.
Results: The detection rate of VEGF was 93.5%. There was a significant difference in the
immunoexpression of VEGF A between the different histological types of carcinoma. However, no
significant differen ces were noted among age groups, tumor sizes, perineural invasion and overall survival.
Conclusion: In our study, VEGF overexpression was positiv ely associated with only the histological
type of breast cancer. Further studies involving patients with advanced diseases are required to establish
an association between the VEGF-A over expression and survival outcomes and to use it as a prognostic
biomarker.

Keywords: Breast cancer, VEGFA, prognosis, histologic type, association.

How to cite : Lepakshi K, Rathnam U, Bapsy P P, Vascular endothelial growth factor –A (VEGF-A) expression as a prognostic factor in breast cancer. Indian J Pathol Oncol 2020;7(1):94-98

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