Immunohistochemical expression of p53 in serous carcinoma of ovary and its correlation with clinicopathological parameters

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Original Article

Author Details : Sunanda Nayak, Pallavi Kumari*, Kailash Chandra Agrawal

Volume : 7, Issue : 1, Year : 2020

Article Page : 33-38

https://doi.org/10.18231/j.ijpo.2020.007

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Abstract

Introduction: Ovarian carcinoma is one of the most prevalent causes of mortality associated with
carcinoma in women. More than 90% of ovarian cancer originates from epithelial cells. Multiple oncogene
and tumour suppressor genes are involved in ovarian carcinogenesis among which p53 gene is found to be
most frequently mutated.
Aim: To study the immunohistochemical expression of p53 in serous carcinoma of ovary and its correlation
with clinico pathological parameters.
Materials and Methods: This study was carried over 18 histopathologically confirmed cases of serous
carcinoma of ovary in VSSIMSR, Burla through a period of 1 year. Analysis of p53 expression was done
immunohistochemically.
Results: Out of total 18 cases of serous carcinoma, 14 cases were high grade and 4 cases were low grade.
While 78.57% (11) cases of HGSOC were diagnosed in advanced stages (FIGO Stage III and IV); advanced
stage (FIGO Stage III) case reported for LGSOC was limited to just 25% (1). Further while only 50%
cases of LGSOC were positive for p53 immunostaining, it was 100% in case of HGSOC. Mean value of
preoperative CA-125 was high in HGSOC as compared to LGSOC.
Conclusion: The significant difference in p53 expression between HGSOC and LGSOC, indicates an
altogether different pathogenesis of these tumours. The aggressive nature of this tumour is also suggested
by the higher preoperative CA-125 values in case of HGSOC and diagnosis at a time when the tumour has
already advanced.

Keywords: Ovary, Serous carcinoma, Low grade serous ovarian carcinoma, (LGSOC), High grade serous ovarian carcinoma
(HGSOC), Immunohistochemistry, p53, CA-125.

How to cite : Nayak S, Kumari P, Agrawal K C, Immunohistochemical expression of p53 in serous carcinoma of ovary and its correlation with clinicopathological parameters. Indian J Pathol Oncol 2020;7(1):33-38

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