Ki67 labeling in CNS tumours

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Author Details : Uttara Mani*, Manjiri Karandikar, Narayanan Subramanian Mani

Volume : 6, Issue : 4, Year : 2019

Article Page : 586-592

https://doi.org/10.18231/j.ijpo.2019.114

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Abstract

A study of Ki67 Labeling Index (LI) by immunohistochemistry was carried out in 47 CNS neoplasms.
Astrocytic and oligodendroglial tumours were the most common group with glioblastoma, NOS and diffuse
astrocytoma, NOS Grade II predominating. Ki67 LI of diffuse astrocytomas varied from 0.72 to 13.9% with
a mean of 4.36%. In glioblastomas the Ki67 LIs varied from 5.96 to 22.4% with a mean of 12.3% which
was comparable with various studies. 1 pleomorphic xanthoastrocytoma was reclassified as anaplastic type
based on a high LI of 21.66%. All histological variants of ependymomas showed uniformly low Ki67 LIs.
Grade I meningiomas show ed a mean Ki67 LI of 2.22% for benign, 5.85% for atypical Grade II and 30%
in the anaplastic Grade III meningioma. Choroid plexus carcinoma and Non Hodgkins lymphomas showed
very Ki67 LIs from 60 to 91%. The findings correlated well with WHO CNS tumour grade and helped to
identify histologically defined lower grade tumours with potential for recurrence and progression.

Keywords: CNS neoplasms, Gliomas, Proliferation markers, Ki67.

How to cite : Mani U, Karandikar M, Mani N S, Ki67 labeling in CNS tumours. Indian J Pathol Oncol 2019;6(4):586-592

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