STUDY OF HISTOPATHOLOGICAL SPECTRUM OF LESIONS OF GALL BLADDER WITH CLINICO RADIOLOGICAL CORRELATION

• Devika Suresh Borade,*  
• Sujata R Kanetkar,  
• Nanda J Patil,  
• Sunil V Jagtap

Abstract

Background: The gallbladder is frequently affected by a spectrum of diseases, ranging from benign inflammatory conditions to aggressive malignancies. Histopathological examination is the cornerstone of diagnosing gallbladder diseases, providing detailed insights into the cellular and tissue-level changes that occur in various conditions. However, the diagnostic process is significantly enhanced when histopathological findings are correlated with clinical and radiological data. Such a multidisciplinary approach not only improves diagnostic accuracy but also improves treatment strategies, leading to better patient outcomes. This study aims to investigate the histopathological spectrum of gallbladder lesions and to establish correlations with clinic-radiological findings, thereby advancing the understanding of gallbladder pathology and its management. Aim and objectives: To study the histopathological spectrum of lesions of gall bladder with clinic radiological correlation Result: The most common histopathological diagnosis was chronic non specific cholecystitis with cholelithiasis seen in 48 cases out of 100 cases (48%). Total 70 cases out of 100 (70%) were calculous out of which 65.71% cases were of chronic cholecystitis, 24.28% cases were of acute cholecystitis and 10% cases were of gall bladder carcinoma with n=70. Out of 100 cases, 90% cases had mixed stones, 7.15% cases had cholesterol stones and 2.85% cases had pigment stones. There were 7 cases (7%) of gall bladder carcinoma amongst 100 cases. All 7 cases were of adenocarcinoma of the gall bladder out of which 2 cases showed serosal invasion and infiltration. Conclusion: Multidisciplinary approach is required in the diagnosis and management of gall bladder diseases, integrating clinical, radiological and histopathological findings to ensure accurate diagnosis. Each and every cholecystectomy specimen must be sent for histopathological examination and studied meticulously, as some unusual findings bearing implications on treatment and prognosis may be seen, regardless of the reason for which cholecystectomy is performed.

Keywords

Gallbladder, Adenocarcinoma, Cholecystitis, Ultrasonography